High Content Imaging (HCI) systems provide quantitative data from cellular assays involving automated microscopy and image analysis. These multi-parametric data sets refer to multiple endpoints and can be obtained from large numbers of cells with higher-throughput, in an observer-independent standardized way.
This information day will focus on the possibilities of the HCI technology for examination of damage mechanisms and toxic effects of chemicals. Probes for organelle and cell function and reporter systems for organ and systemic toxicity will be presented. The discussion will address questions on how phenotypic and signaling changes are linked to functional impairment and cell fate. Furthermore, the implementation of the HCI approach in (regulatory) safety sciences, latest technical advances and perspectives from the fields of systems biology/toxicology will be important topics during this event.