Building on progress since a successful “AOPs 101” seminar at the Society of Toxicology meeting in 2014, the Human Toxicology Project Consortium and the Physicians Committee for Responsible Medicine invite you to learn a bit more about Adverse Outcome Pathways and the tools and guidance that are available to help you develop and record them. Case studies of AOPs in various stages of development will be presented to demonstrate the major steps one would take in developing an AOP.
5:00-5:25: AOPs: Overview of AOP Development and Introduction to Regulatory Use - Catherine Willett, HTPC
5:25-6:25: The AOP-Knowledgebase, with demos of the AOP Wiki, Effectopedia, and AOP Explorer (+ questions) - Ed Perkins, US Army Engineer Research and Development Center, Steven Edwards, US EPA, Hristo Aladjov, OECD
6:25-6:40: Aromatase inhibition leading to reproductive dysfunction in fish: A quantitative AOP case study - Rory Conolly, EPA
6:40-6:55: AOP for Sensitisation of the Respiratory Tract: Current status and regulatory applications - Kristie Sullivan, PCRM
6:55—7:10: AOP Assessment According to OECD Handbook Criteria - Bette Meek, University of Ottawa
Light refreshments served